WebMar 8, 2024 · Our data indicated that cell damage induced by cisplatin activated TIM3 on CD8+ T cells, leading to increased IL-13 production, which in turn induced macrophage IL-10 production and resolution of CIPN. Development of exogenous activators of the IL-13/IL-10 pain resolution pathway may provide a way to treat the underlying cause of chronic pain. WebMar 18, 2024 · Salvagno et al. 4 found that neutrophils, but not macrophages, limit tumour response to cisplatin by suppressing CD8 + …
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WebCisplatin does not affect the phenotype of CAMs, or the anti-tumor and chemo-sensitivity effects of CAMs on ovarian cancer cells. (A) mRNA expression of macrophage polarization markers as... WebOct 18, 2016 · Macrophages are the main component of inflammatory cells, and macrophages that infiltrate into the tumour microenvironment are referred to as tumour-associated macrophages (TAMs). ... Pirfenidone was recently reported to induce apoptosis of CAFs and to increase the anti-tumour effect of cisplatin in a murine model; however, … population of town of horseheads ny
Cisplatin does not affect the phenotype of CAMs, or the
WebSep 13, 2024 · Our findings in cisplatin-induced injury underscore the value of dissecting the functions of individual MP subsets in kidney disease, which may enable therapeutic targeting of specific immune components in the absence of general immunosuppression. Sign up for PNAS alerts. Get alerts for new articles, or get an alert when an article is cited. WebJul 1, 2013 · Cisplatin is widely used to treat cancer, and one of its limiting side effects is acute kidney injury characterized by acute tubular necrosis … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. Ubiquitin-specific protease (USP14) is involved in various pathological conditions ... population of town of tonawanda ny