Cral-trio lipid binding domain

Author: fibw

August undefined, 2024

WebDec 1, 2024 · SEC14/CRAL-TRIO and GOLD domains govern membrane binding specificity. ... Saito K, Tautz L, Mustelin T (2007a) The lipid-binding SEC14 domain. Biochim Biophys Acta 1771:719–726. Saito K ... WebSpecific lipid-binding protein domains, such as PH, FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions between proteins and specific phospholipids. Here we review the published literature, plus some of our most recent unpublished findings, regarding the biology of the SEC14 domain, also known as CRAL_TRIO domain.

Gene Expression of CRAL_TRIO Family Proteins …

WebDec 1, 2024 · Many lipid transfer proteins remain unstudied, even those that have an essential function, including PF3D7_0920700, a predicted Sec14/CRAL/TRIO phospholipid transfer protein, and PF3D7_1324400, a PRELI domain-containing protein predicted to be involved in phospholipid and phosphatidic acid transport (Table 1). WebThe Sec14 domain is depicted in yellow with N-terminal CRAL-TRIO domain as an oval structure. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] from ... shell bray

C34C12.6 CRAL-TRIO domain-containing protein …

WebAug 23, 2024 · The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. [3] Structure. The Sec14 protein was the first CRAL-TRIO domain for which the structure was determined. [4] The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and … WebAug 1, 2008 · • Proteins containing the lipid-binding Sec14 domain, also referred to as the CRAL-TRIO domain, ar e found throughout eukaryotic organisms ranging from yeast to humans. splits collection

Membranes Free Full-Text Transmembrane Membrane Readers …

Web3.40.525.10 CRAL-TRIO lipid binding domain 1 hit; 1.10.8.20 N-terminal domain of phosphatidylinositol transfer protein sec14p 1 hit; ... IPR036865 CRAL-TRIO_dom_sf; IPR011074 CRAL/TRIO_N_dom; IPR036273 CRAL/TRIO_N_dom_sf; PANTHER. PTHR45657 CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED 1 hit; … WebApr 7, 2024 · The main feature of the CRAL-TRIO domain is that it possesses a cavity to specifically host a lipophilic molecule. CRAL-TRIO domain-containing proteins belong to the large category of lipid transfer proteins (Chiapparino et al., 2016). Sec14p can exchange glycerophospholipids (PI and PC) between membranes, whereas retinaldehyde-binding … shell brent alphaWebCRAL-TRIO lipid binding domain superfamily PH-like domain superfamily Ras GTPase-activating domain Ras GTPase-activating protein Ras GTPase-activating protein, conserved site Rho GTPase activation protein; UniProtKB:X1WCU2. InterPro 59: UniProtKB:X1WE29. InterPro ... split scimitar winglet cost

"WebThe CRAL-TRIO domain is a structurally conserved element of about 170 amino acids, which constitute a hydrophobic lipid binding pocket. The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and ... " - Cral-trio lipid binding domain

Cral-trio lipid binding domain

A Sec14 domain protein is required for photoautotrophic growth …

WebSep 1, 2009 · ProNGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). By similarity. ... 3.40.525.10 CRAL-TRIO lipid binding domain 1 hit; 1.20.900.10 Dbl homology (DH) domain 2 hits; ... SSF52087 CRAL/TRIO domain 1 hit; SSF48065 DBL homology domain (DH-domain) 2 hits; WebNov 1, 2024 · CRAL_TRIO family proteins are cytosolic and contain the SEC14 carboxy-terminal domain [7,9]. The CRAL_TRIO subgroup derives its name from the cellular retinaldehyde-binding protein (CRALBP) and the TRIO guanine exchange factor [11]. SEC14 was originally shown to be a cytosolic factor that promotes protein export from …

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WebJan 6, 2024 · A small N-terminal lobe, referred to as a CRAL_TRIO_N domain (Pfam, PF03765), closes off one end of the lipid-binding pocket with an all-helical tripod-like fold that can interact with bound lipid ... WebApr 24, 2024 · Orthologous to human SEC14L2 (SEC14 like lipid binding 2); SEC14L3 (SEC14 like lipid binding 3); and SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Apr 2024] C34C12.6 CRAL-TRIO domain-containing protein C34C12.6 [] ... CRAL-TRIO domain-containing protein C34C12.6 ...

WebMay 10, 2016 · The deduced 354-amino acid protein contains a conserved CRAL-TRIO domain (residues 118-279) that is 45% identical to that in cellular retinaldehyde-binding protein (CRALBP, or RLBP1; 180090). The CRAL-TRIO domain is present in members of the lipid-binding SEC14-like proteins. RT-PCR analysis of 18 human tissues showed … WebCRAL-TRIO lipid binding domain which includes the vitamin E binding protein TTP (SMART-SM00516; PFAM-PF00650). The defining protein of this family is the yeast phospholipid transfer protein Sec14, containing a phospholipid binding cavity with a floor made of four parallel and two antiparallel beta-strands. Several α-helices cover the β …

WebLipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. Interpro abstract : The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules [ (PUBMED:12767229) ]. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine … Webtriob. Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Human ortholog (s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and ...

WebThe lipid binding cavity is shown in grey, the CRAL/TRIO_N domain in navy, the Sec14 domain in turquoise-green, and the GOLD domain in yellow-orange (as on the scheme in Fig. 1.2). Taken from ...

WebApr 3, 2024 · The bipartite sequence motif is composed of CRAL_TRIO_C and N domains, with CRAL_TRIO_C forming the lipid-binding pocket. ( B ) Subcellular localization of CPSFL1-YFP. shell breadWebSeveral CRAL-TRIO domain proteins have been shown to bind phospholipids in addition to their hydrophobic ligand (27,28), prompting us to test whether the CPSFL1 protein is capable of binding ... split scimitar winglets wikipediaWebApr 21, 2024 · Important regulators of PI phosphorylation and distribution are proteins harboring a CRAL_TRIO (cellular retinaldehyde binding-triple response) domain, for which yeast Sec14 is the prototype (2, 3). Sec14-like proteins bind PI in a hydrophobic cavity in the CRAL_TRIO domain. In that cavity, another hydrophobic ligand can be bound alternatively. splits counsellingWebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. CRALB proptein carries 11-cis-retinol or 11-cis-retinaldehyde. It is a carrier that modulates interaction of retinoids with visual cycle enzymes. splits con barraWebMay 15, 2010 · The activation of the protein kinase Raf at the cell membrane is a critical step in cell signaling during development, but the mechanisms that regulate Raf activity remain incompletely defined. We previously demonstrated that the C. elegans cgr-1 gene encodes a CRAL/TRIO domain-containing protein that is a critical modulator of Ras … shell bredaWebSuperfamily assignments for Oryza sativa ssp. Indica . Summary assignment statistics followed by sortable table of detailed assignments with number of domains, proteins and families assigned for each superfamily. splits.comWebIt engages lipid droplets via its CRAL-TRIO domain, which specifically recognizes packing defects and negatively charged phospholipids . This module is also referred to as the SEC14 domain, and is known to bind PI lipids [ 124 , 125 ]. shell brent decommissioning